Creating cellular diversity through transcription factor competition.
نویسنده
چکیده
The development of blood cells has long served as a model system to study the generation of diverse mature cells from multipotent progenitors. The article by Org et al (2015) reveals how transcription factor competition on primed DNA templates may contribute to embryonic blood cell specification during the early stages of mesoderm development. The study not only provides new insights into the functionality of the key haematopoietic transcription factor Scl/Tal1, but also provides a potentially widely applicable framework for transcription factormediated cell fate specification.
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عنوان ژورنال:
- The EMBO journal
دوره 34 6 شماره
صفحات -
تاریخ انتشار 2015